The Use of Isothermal Solution Calorimetry as a Promising Technique to Monitor Drug Release Kinetics

The objective of the present article is to emphasize that isothermal solution calorimetry (ISC) can be used determine kinetics reactions interest in biotechnology. major advantage this technique it enables characterize drug release profiles real time noninvasively. Here ISC was monitor pyrimethamine incorporated hydrogels oxidized alginate, ADA, and alginate blended with chitosan, ADA-Chit. mechanism analysed using semi-empirical equation so-called power law. From plots cumulative heats concerning release, Qrel(t), versus time, values apparent rate k, diffusion exponent, n, were determined. n found 1.22 for ADA 1.09 ADA-Chit, indicating controlled by polymer relaxation.